Service: Chemistry, in vitro/in vivobiology, DMPK, non-GLP tox, formulation, process chemistry and GMPproduction.

Note: The biggest Chinese CRO( 4000 employees) with the 1st certified GMPproduction/manufacturing in China, currently in the process ofbeing acquired by Charles River Laboratories.

http://www.wuxiapptec.com.cn/

2.上海睿智（上海）

Service: Chemistry, in vitro/in vivobiology, DMPK, non-GLP tox, formulation, processchemistry.

Note: The 2nd biggest CRO in China (~2000employees). A multi-ton scale production facility underconstruction. The firm is preparing for an IPO.

http://www.chempartner.cn/index.php?id=41

3.桑迪亚（上海）

Service: Chemistry, in vitro/in vivobiology, DMPK, non-GLP tox, formulation, process chemistry and GMPkilo lab.

Note: IP-protected SELO platform formolecular modeling.

http://www.sundia.com/

4.美迪西普亚（上海）

Service: Chemistry, in vitro/in vivobiology, DMPK, formulation, GLP tox/PK.

Note: Sister companies: one forpre-clinical discovery services and the other (JV with MPI) for GLPservices; government license on working withradio-isotopes.

http://www.mediciloninc.com/

5.康龙化成（北京）

Service: Chemistry, in vitro/in vivobiology, DMPK, formulation, GLP tox PK, processdevelopment.

Note: Recently acquired BridgeLaboratories China and added GLP services.

http://www.pharmaron.com/

6.凯美药业（北京）

Service: Chemistry, in vitro biology,DMPK, formulation, process development.

Note: A division of Optomagic, a Koreanpublic listed company (KOSDAQ:010170).

http://www.chemizon.com/

7.PPD（北京）

Service: Chemistry, in vitro/in vivobiology, DMPK, formulation, GLP tox PK, process development,clinical trials.

Note: Recently acquired ExcelPharmaStudies and BioDuro. Provides full range services frompre-clinical discovery, GLP to clinical trials anddevelopment.

http://www.ppdi.com/services/

7.凯莱英（天津）

Service: Chemistry (synthesis andanalytical), formulation, GMP production, APImanufacturing.

Note: One of the few CROs to provide UScGMP-compliant formulation beyond API raw materials.

http://www.asymchem.com/en/index.aspx

8.复星普适（上海）

Service: Drug delivery, formulation andstability.

Note: One of the few CROs to provideextended release and inhalation formulation services.

http://www.omni-pharma.com.cn/

9.奥浦顿（上海）

Service: Chemistry and compoundlibraries.

Note: A high-throughput parallel synthesisplatform acquired from ArQule Inc. (USA).

http://www.alputon.com/

10. 查尔斯河试验室（上海）

Service: Pre-clinical GLP tox andPK.

Note: A Chinese division of the well-knownmulti-national CRO.

http://www.criver.com/en-US/Pages/home.aspx

11.华大天源（上海）

Service: In vitro/in vivo biology, assaydevelopment, high-throughput screening.

Note: Specialized in pre-clinical biology.Investors include Lilly and Pfizer ventures.

http://www.hdbiosciences.com/

12.中美冠科（北京）

Service: In vitro/in vivo biology, protein assay development,biomarkers.

Note: Specialized in pre-clinical oncologyser vices. Provide human primary tumor xenograft models.

http://www.crownbio.com/

13.方达医药（上海）

Service: ADME, bioanalysis and GLP-PK studies.

Note: More service, for example clinicalstudies can be provided through the company’s US parent.

http://www.frontagelab.com.cn/en/index.asp

14.吉玛制药（上海）

Service: Chemistry, siRNA monomers, andoligo design, synthesis.

Note: A leading supplier of siRNA in Chinaand one of the rare CROs providing siRNA monomers and oligomers. Akilo lab under construction.

http://www.genepharma.com/

15.金斯瑞（南京）

Service: Bio-reagents, antibodies,molecular biology.

Note: One of the few CRO offeringbiological reagents. Large scale protein production underconstruction.

http://www.genscript.com/

16.泰格医药（上海）

Service: Regulatory affairs, clinicaltrials.

Note: One of the best known Chineseclinical CROs providing Western style clinical developmentservices.

http://www.tigermed.net/

17.润东科若华（上海）

Service: Regulatory affairs, clinicaltrials.

Note: A JV with the Japanese CROCronova.

http://www.rundo-cro.com/En/Menu.aspx?typeid=11

Reference: Drug Discovery Today. 2010, 15,693-697.